Pulmonary complications of infliximab therapy in patients with rheumatoid arthritis.
case_report · Level V
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- Record sourced from PubMed, PMID 16511933.
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Abstract
We describe 5 patients with rheumatoid arthritis (RA) who developed pulmonary complications following infliximab therapy; 4 patients had preexisting usual interstitial pneumonia. As the pathophysiology of the pulmonary insult is unknown, we advise caution in the use of anti-tumor necrosis factor-alpha therapy in patients with RA with underlying lung disease of sufficient severity to withhold methotrexate treatment.
Medical subject headings
- Antibodies, Monoclonal
- Antirheumatic Agents
- Arthritis, Rheumatoid
- Lung Diseases, Interstitial
- Tumor Necrosis Factor-alpha