Coming up for air: HIF-1 and mitochondrial oxygen consumption.
editorial · Level V
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Abstract
Hypoxic cells induce glycolytic enzymes; this HIF-1-mediated metabolic adaptation increases glucose flux to pyruvate and produces glycolytic ATP. Two papers in this issue of Cell Metabolism (Kim et al., 2006; Papandreou et al., 2006) demonstrate that HIF-1 also influences mitochondrial function, suppressing both the TCA cycle and respiration by inducing pyruvate dehydrogenase kinase 1 (PDK1). PDK1 regulation in hypoxic cells promotes cell survival.
Medical subject headings
- Hypoxia-Inducible Factor 1
- Mitochondria
- Oxygen Consumption