A long-distance relationship between RNAi and Polycomb.
review · Level V
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Abstract
RNA interference (RNAi) pathways can result in sequence-specific transcriptional gene silencing on the level of chromatin. In this issue of Cell, Grimaud et al. (2006) reveal that the RNAi machinery is required for long-distance physical interactions between chromosomes mediated by the Polycomb repressive complex. These results suggest that the RNAi machinery may regulate higher-order nuclear organization.
Medical subject headings
- Chromosomes
- Drosophila Proteins
- Gene Silencing
- RNA Interference