TOPping up ATR activity.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 16530035.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.
Medical subject headings
- Carrier Proteins
- Cell Cycle Proteins
- Protein Serine-Threonine Kinases
- Xenopus Proteins