TGF-beta regulation by Emilin1: new links in the etiology of hypertension.
editorial · Level V
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Abstract
Hypertension is a complex disease influenced by multiple genetic and environmental factors. The TGF-beta signaling pathway has a long recognized role in blood pressure homeostasis. In this issue of Cell, Zacchigna et al. (2006) report that the secreted protein Emilin1 is a negative regulator of TGF-beta signaling. Emilin1 knockout mice display elevated blood pressure due to increased TGF-beta signaling in the vasculature.
Medical subject headings
- Hypertension
- Membrane Glycoproteins
- Signal Transduction
- Transforming Growth Factor beta