Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device.
basic_science · Level V
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- Record sourced from PubMed, PMID 16531991.
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Abstract
Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled pulsatile release of the polypeptide leuprolide from microchip implants over 6 months in dogs. Each microchip contains an array of discrete reservoirs from which dose delivery can be controlled by telemetry.
Medical subject headings
- Drug Therapy, Computer-Assisted
- Infusion Pumps, Implantable
- Leuprolide
- Microfluidic Analytical Techniques
- Telemetry