Evaluation of NaOH treatment of human dura mater implants to obviate Creutzfeldt-Jakob disease transmission.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 1653623.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
One of the few disinfectants known to inactivate the causative agent of Creutzfeldt-Jakob Disease is NaOH. In this study, NaOH was evaluated as a possible routine treatment for human dura mater alloimplants. Use of high concentration NaOH (1 M) resulted in protein loss and macroscopic changes to the tissue. Lower concentrations (0.1 M), although exhibiting little direct detrimental effect, greatly increased the susceptibility of the tissue to collagenase digestion. The use of NaOH treated commercial or institutionally prepared human dura mater should be approached with caution.
Medical subject headings
- Creutzfeldt-Jakob Syndrome
- Dura Mater
- Sodium Hydroxide