Suppressing Brownian motion of individual biomolecules in solution.
basic_science · Level V
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- Record sourced from PubMed, PMID 16537418.
- Also identified by PMC identifier 1450176.
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Abstract
Single biomolecules in free solution have long been of interest for detailed study by optical methods, but Brownian motion prevents the observation of one single molecule for extended periods. We have used an anti-Brownian electrokinetic (ABEL) trap to trap individual protein molecules in free solution, under ambient conditions, without requiring any attachment to beads or surfaces. We also demonstrate trapping and manipulation of single virus particles, lipid vesicles, and fluorescent semiconductor nanocrystals.
Medical subject headings
- Motion
- Optics and Photonics
- Virion