Cardiac myosin-induced myocarditis as a model of postinfectious autoimmunity.
basic_science · Level V
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Abstract
Immunization with purified cardiac myosin induces autoimmune myocarditis in A strain mice. Because this disease parallels Coxsackievirus B3 (CB3)-induced myocarditis in many respects, we are now using the immunization model as a virus-free system to study certain forms of immunologically-mediated heart disease. In the present article we will describe several characteristics of the humoral and cellular autoimmune response acting in myosin-induced myocarditis. Furthermore, we discuss hypotheses which might explain how myosin-reactive T cells recognize and attack the heart tissue.
Medical subject headings
- Autoantibodies
- Autoimmune Diseases
- Myocarditis
- Myosins