Connecting cancer to the asymmetric division of stem cells.
review · Level V
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Abstract
Two studies, one in this issue of Cell and the other in Developmental Cell show that the cell-fate determinant Brain Tumor (Brat) suppresses self-renewal in one of the daughter cells that arise from the asymmetric division of a neural stem cell. This work suggests a mechanism by which loss of polarity in stem cells may lead to tumorigenesis.
Medical subject headings
- Cell Division
- Neoplasms
- Stem Cells