Increasingly irritable and close to tears: TRPA1 in inflammatory pain.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 16564004.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
TRP cation channels transduce mechanical, thermal, and pain-related inflammatory signals. In this issue of Cell, it is reported that TRPA1 has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, including those found in tear gas and garlic. In contrast, mechano- and thermosensation are normal in TRPA1-deficient mice.
Medical subject headings
- Inflammation
- Pain
- Tear Gases
- Transient Receptor Potential Channels