The KEOPS complex: a rosetta stone for telomere regulation?
review · Level V
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Abstract
The detailed mechanisms underlying telomere capping and its relationship to telomerase activity are still unclear, although many proteins have been implicated in either or both processes. In this issue of Cell, the surprising identification of a new complex, called KEOPS, which promotes both telomere uncapping and elongation is presented.
Medical subject headings
- Gene Expression Regulation, Enzymologic
- Telomerase
- Telomere