Generation of cloned transgenic pigs rich in omega-3 fatty acids.
basic_science · Level V
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- Record sourced from PubMed, PMID 16565727.
- Also identified by PMC identifier 2976610.
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Abstract
Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001).
Medical subject headings
- Animals, Genetically Modified
- Cloning, Organism
- Fatty Acids, Omega-3
- Protein Engineering
- Swine