Role reversal: brain insulin and liver STAT3.

Myers, Martin G · Cell Metab · 2006

editorial · Level V

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Abstract

The central nervous system (CNS) actions of several hormones, including insulin, regulate metabolism in the liver and other peripheral tissues. Inoue et al. (2006) have now identified an IL-6/STAT3-dependent pathway in the liver that mediates a portion of the hepatic metabolic response to CNS insulin.

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