Opioidergic changes in the pineal gland and hypothalamus in cluster headache: a ligand PET study.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 16606930.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Using PET with the opioidergic ligand [11C]diprenorphine, the authors demonstrate decreased tracer binding in the pineal gland of cluster headache patients vs healthy volunteers. Opioid receptor availability in the hypothalamus and cingulate cortex depended on the duration of the headache disorder. Therefore, the pathophysiology of cluster headache may relate to opioidergic dysfunction in circuitries generating the biologic clock.
Medical subject headings
- Cluster Headache
- Diprenorphine
- Hypothalamus
- Narcotic Antagonists
- Pineal Gland