Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects.
basic_science · Level V
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Abstract
We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.
Medical subject headings
- Glioblastoma
- Microscopy, Fluorescence
- Neovascularization, Pathologic
- Oligopeptides
- Quantum Dots
- Spectrophotometry, Infrared