Arteriolar remodeling in essential hypertension: are connective tissue growth factor and transforming growth factor involved?
Level V
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Abstract
Gómez-Garre et al. report increased expression of connective tissue growth factor and transforming growth factor-beta and worsening of remodeling in subcutaneous arterioles of patients with essential hypertension during amlodipine treatment. Losartan improves remodeling without changes in cytokine expression. The discordant effects of two well-accepted treatments for hypertension underline the need for further studies on therapy-induced changes in arteriolar remodeling.
Medical subject headings
- Arterioles
- Hypertension
- Immediate-Early Proteins
- Intercellular Signaling Peptides and Proteins
- Transforming Growth Factor beta