Variant angina associated with bitter orange in a dietary supplement.

Gange, Christopher A; Madias, Christopher; Felix-Getzik, Erika M; Weintraub, Andrew R; Estes, N A Mark · Mayo Clin Proc · 2006

case_report · Level V

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Abstract

The Food and Drug Administration has banned the sale of ephedrine-based weight-loss products because of their association with many cardiovascular adverse effects. Bitter orange is now being used as a stimulant in "ephedra-free" weight-loss supplements but was recently implicated in adverse cardiovascular sequelae. To our knowledge, this report describes the first case of variant angina associated with bitter orange in a dietary supplement.

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