Failure to eradicate HIV despite fully successful HAART initiated in the first days of life.
case_report · Level V
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- Record sourced from PubMed, PMID 16615974.
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Abstract
Highly active antiretroviral therapy (HAART) started shortly after birth resulted in reversion of human immunodeficiency virus (HIV) plasma viremia, proviral DNA in PBMC, viral culture, and serum HIV antibodies to negative. Discontinuation of HAART 2 years after apparent HIV eradication, however, was followed by virus replication, CD4 decline, and destruction of HIV-specific lymphocytes, epitomizing the impossibility of HIV eradication.
Medical subject headings
- Antiretroviral Therapy, Highly Active
- HIV Infections
- HIV-1
- Virus Replication