Toxicity of hydroxyapatite in vitro: the effect of particle size.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 1663393.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Finely ground powders of synthetic hydroxyapatite applied to fibroblasts in vitro reduced the total growth rate and mitotic rate of the cells and increased the number of pycnotic cells. The effect was dose related and only occurred with small particles. The small particles appear to either adhere to the cells or are phagocytosed by them and the toxic effect may be physical rather than chemical.
Medical subject headings
- Biocompatible Materials
- Hydroxyapatites