The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection.
case_control · Level III
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Abstract
In a primary study on proinflammatory genetic profiles in stroke, the authors found the E469K polymorphism of the intercellular adhesion molecule 1 (ICAM-1) highly represented in the subgroup with spontaneous cervical artery dissection (sCAD). They further investigated the same genetic variant in a second group of 65 patients with sCAD. An association between sCAD and EE genotype was confirmed (odds ratio 3.16; p < 0.01), indicating that a proinflammatory predisposition is a risk factor for sCAD.
Medical subject headings
- Glutamic Acid
- Intercellular Adhesion Molecule-1
- Lysine
- Polymorphism, Genetic
- Vertebral Artery Dissection