Descrambling Dscam diversity.
review · Level V
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Abstract
Neuronal processes exhibit exquisitely complex branching patterns crucial for the formation of distinct neural circuits. In this issue of Cell, Chen et al. (2006) show that the isoform diversity of the Dscam protein in Drosophila is required to establish stereotypical axonal branching patterns, suggesting that nonrandom expression of Dscam alternative splice variants determines neural connectivity.
Medical subject headings
- Cell Differentiation
- Central Nervous System
- Drosophila Proteins
- Drosophila melanogaster
- Growth Cones