Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis.
other · Level V
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- Record sourced from PubMed, PMID 16685656.
- Also identified by PMC identifier 1474106.
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Abstract
In a systematic analysis of global gene-expression patterns, we found that SOCS3 messenger RNA was significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls, and immunohistochemical analysis confirmed a similar elevation of SOCS3 protein. Furthermore, we found a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene in two independent groups of patients (P<.02 and P<.03). These results strongly suggest that SOCS3, located in a chromosomal region previously linked to the disease (17q25), is a susceptibility gene for atopic dermatitis.
Medical subject headings
- Dermatitis, Atopic
- Gene Expression
- Genetic Linkage
- Suppressor of Cytokine Signaling Proteins