Perspectives on blockade of TGFbeta overexpression.
editorial · Level V
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Abstract
Many approaches to blocking profibrotic TGFbeta overexpression are under way. Therapeutic targeting of TGFbeta-Smad signaling holds promise for slowing or halting progressive renal disease. In this issue, Fukasawa et al., using the unilateral ureteral obstruction model, provide a new target for therapeutic intervention by identifying loss of the Smad corepressors Ski and SnoN as a mechanism that amplifies the profibrotic actions of TGFbeta.
Medical subject headings
- DNA-Binding Proteins
- Proto-Oncogene Proteins
- Transforming Growth Factor beta