Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer.
review · Level V
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Abstract
Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-beta superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis and management of a wide range of cancers. Although generally considered to be part of the cell's antitumorigenic repertoire, MIC-1 secretion, processing, and latent storage suggest a complex, dynamic variability in MIC-1 bioavailability in the tumor microenvironment, potentially modulating tumor progression and invasiveness.
Medical subject headings
- Biomarkers, Tumor
- Cell Transformation, Neoplastic
- Cytokines
- Neoplasms