CYLD in ubiquitin signaling and tumor pathogenesis.
review · Level V
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Abstract
Absence of CYLD, which encodes a deubiquitinating enzyme, causes an inherited disease characterized by benign skin tumors. In this issue of Cell, Massoumi et al. (2006) show that CYLD deubiquitinates the coactivator Bcl-3, thereby preventing its translocation into the nucleus, where it normally interacts with NF-kappaB and activates transcription of proliferation genes in response to growth signals.
Medical subject headings
- Neoplasms
- Signal Transduction
- Tumor Suppressor Proteins
- Ubiquitin