The ataxia-ome: connecting disease proteins of the cerebellum.
review · Level V
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Abstract
In this issue of Cell, Lim et al. (2006) describe a protein-protein interaction network for inherited human ataxias, a group of diseases characterized by degeneration of cerebellar Purkinje cells. This protein interactome shows that the cerebellar ataxias not only share clinical and pathological characteristics but also have proteins, processes, and pathways in common.
Medical subject headings
- Ataxia
- Cerebellum
- Nerve Tissue Proteins