Diagnostic evaluation of clinically normal subjects with chronic hyperCKemia.
retrospective_cohort · Level III
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Abstract
The authors analyzed muscle biopsy specimens of 104 patients with creatine kinase activity greater than 500 UI/L (normal 10 to 170 UI/L) without signs of muscle weakness. They achieved a definite or probable diagnosis in 55% of cases. The most frequently identified diseases were glycogen storage diseases, muscular dystrophies, and inflammatory myopathies. The probability of making a diagnosis was higher in children and when creatine kinase level was greater than 2,000 UI/L.
Medical subject headings
- Creatine Kinase, MM Form
- Neuromuscular Diseases