Effects of circuit miniaturization in reducing inflammatory response to infant cardiopulmonary bypass by elimination of allogeneic blood products.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 16731105.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Conventional neonatal cardiopulmonary bypass requires the use of large volumes of allogeneic blood to prevent unacceptable hemodilution. Evidence is accumulating to suggest that the use of blood products during cardiopulmonary bypass has a negative effect on clinical recovery through inflammatory side effects. This would suggest an advantage for eliminating blood use in infant cardiopulmonary bypass through circuit miniaturization. In this article, we review the data supporting this rationale and provide the results from studies in our laboratory that emphasize the benefits of circuit miniaturization.
Medical subject headings
- Cardiopulmonary Bypass
- Systemic Inflammatory Response Syndrome