The autoimmune regulator (Aire) controls iNKT cell development and maturation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 16732280.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1.
Medical subject headings
- Killer Cells, Natural
- Polyendocrinopathies, Autoimmune
- T-Lymphocyte Subsets
- Transcription Factors