A phosphatase controls the fate of receptor-regulated Smads.
editorial · Level V
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Abstract
In this issue of Cell, Lin et al. (2006) answer one of the long-standing questions in the TGFbeta field by identifying a phosphatase, PPM1A, that directly dephosphorylates Smad2 and Smad3 to limit their activation.
Medical subject headings
- Phosphoprotein Phosphatases
- Smad2 Protein
- Smad3 Protein
- Transforming Growth Factor beta