CAT in the HAT: catabolic inhibition by the histone acetyltransferase GCN5.
review · Level V
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Abstract
The nuclear hormone receptor coactivator PGC-1alpha is a key regulator of gluconeogenic genes during fasting. In this issue of Cell Metabolism, Puigserver and colleagues (Lerin et al., 2006) report that the histone acetyltransferase GCN5 inhibits gluconeogenesis by acetylating and sequestering PGC-1alpha in nuclear foci.
Medical subject headings
- Fasting
- Gluconeogenesis
- Heat-Shock Proteins
- Histone Acetyltransferases
- Trans-Activators
- Transcription Factors