Hap1 and GABA: thinking about food intake.
review · Level V
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Abstract
GABA stimulation of hypothalamic GABAA receptors increases food intake and body weight. Huntingtin-associated protein-1 (Hap1), is highly expressed in the hypothalamus and increases activity at GABAA receptors; mice lacking Hap1 are hypophagic. A recent paper (Sheng et al.,2006) further explores the role of Hap1 in the control of food intake.
Medical subject headings
- Eating
- Feeding and Eating Disorders
- Hypothalamus
- Nerve Tissue Proteins
- Receptors, GABA-A
- gamma-Aminobutyric Acid