Cellular mechanisms of WNK4-mediated regulation of ion transport proteins in the distal tubule.
basic_science · Level V
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Abstract
Gene mutations in WNK4 kinase cause a genetic form of hypertension by affecting multiple ion transport pathways through different mechanisms. Cai et al. report that the inhibitory effect of WNK4 on the thiazide-sensitive sodium-chloride cotransporter occurs through the lysosomal degradation pathway in mammalian cells.
Medical subject headings
- Carrier Proteins
- Ion Transport
- Kidney Tubules, Distal
- Protein Serine-Threonine Kinases