The effect of the cut surface during electrical stimulation of a cardiac wedge preparation.
basic_science · Level V
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- Record sourced from PubMed, PMID 16761846.
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Abstract
Optical mapping from the cut surface of a "wedge preparation" allows observation inside the heart wall, below the epicardium or endocardium. We use numerical simulations based on the bidomain model to illustrate how the transmembrane potential is influenced by the cut surface. The distribution of transmembrane potential around a unipolar cathode depends on the fiber angle. For intermediate angles, hyperpolarization appears on only one side of the electrode, and is large and widespread.
Medical subject headings
- Action Potentials
- Body Surface Potential Mapping
- Cardiac Pacing, Artificial
- Electric Stimulation Therapy
- Heart Conduction System
- Models, Cardiovascular
- Tissue Culture Techniques