A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 16767078.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The value of predictive algorithms for identifying CD8+ T (T(CD8+))-cell epitopes has not been adequately tested experimentally. Here we demonstrate that conventional bioinformatic methods predict the vast majority of T(CD8+)-cell epitopes derived from vaccinia virus WR strain (VACV-WR) in the H-2(b) mouse model. This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any complex pathogen.
Medical subject headings
- CD8-Positive T-Lymphocytes
- Computational Biology
- Epitope Mapping
- Epitopes, T-Lymphocyte
- Vaccinia virus