Prostaglandin F2alpha increases the sensitivity of the contractile proteins to Ca2+ in human myometrium.
basic_science · Level V
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Abstract
It is not known whether agonists (other than oxytocin) increase the contractile protein sensitivity to intracellular calcium ([Ca2+]i) in human myometrium. We determined the calcium-tension relationship in the presence and absence of prostaglandin F2alpha (PGF2alpha). PGF2alpha increased the calcium sensitivity during both the contractile (rising) and relaxation (falling) phases of a contraction.
Medical subject headings
- Calcium
- Contractile Proteins
- Dinoprost
- Intracellular Membranes
- Myometrium
- Uterine Contraction