Endothelial dysfunction in MELAS improved by l-arginine supplementation.
case_series · Level IV
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Abstract
The authors evaluated endothelial function in patients with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke) by flow-mediated vasodilation (FMD) and found a significant decrease vs controls. Two years of supplementation with oral l-arginine, a nitric oxide precursor, significantly improved endothelial function to control levels and was harmonized with the normalized plasma levels of l-arginine in patients. l-Arginine therapy improved endothelial dysfunction and showed promise in treating strokelike episodes in MELAS.
Medical subject headings
- Arginine
- Cerebrovascular Circulation
- Endothelium, Vascular
- MELAS Syndrome
- Stroke