Tau protein hyperphosphorylation in sporadic ALS with cognitive impairment.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 16769962.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The authors have characterized frontal cortical tau protein in cognitively intact (4) and cognitively impaired (ALSci, 4) ALS patients and compared it with control (2) or Alzheimer disease (AD, 1)- derived tau. The authors observed expression of both 3R and 4R tau isoforms; increased insoluble tau protein; phosphatase resistance; and hyperphosphorylation at T175, S208, and S210. Soluble tau from both AD and ALSci was also phosphorylated at S237. Tau hyperphosphorylation is associated with ALS.
Medical subject headings
- Amyotrophic Lateral Sclerosis
- Cognition Disorders
- tau Proteins