Transcriptional pausing caught in the act.
basic_science · Level V
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Abstract
Single-molecule techniques now permit the tracking of a transcription complex along a DNA template in real time and to 1 bp resolution. As reported in this issue of Cell, Herbert et al. (2006) exploit this approach to study a central component of transcription regulation, the sequence-dependent pausing of RNA polymerase during transcript elongation.
Medical subject headings
- DNA-Directed RNA Polymerases
- Transcription, Genetic