Exploring transcriptional regulatory networks in the worm.
basic_science · Level V
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Abstract
Using a yeast one-hybrid assay, Deplancke et al. (2006) report in this issue a protein-DNA interaction network for 72 gene promoters and 117 regulatory proteins expressed in cells of the nematode digestive tract. This study is a first step toward mapping transcriptional regulatory networks in distinct metazoan cell lineages and organs using a "gene-centered" approach.
Medical subject headings
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- DNA, Helminth
- DNA-Binding Proteins
- Transcription, Genetic