Fatty acid synthase and cancer: new application of an old pathway.
review · Level V
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- Record sourced from PubMed, PMID 16778164.
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Abstract
Fatty acid synthase (FAS), the sole mammalian enzyme capable of de novo fatty acid synthesis, is highly expressed in most human carcinomas. FAS is associated with poor prognosis in breast and prostate cancer, is elaborated into the blood of cancer patients, and its inhibition is selectively cytotoxic to human cancer cells. Thus, FAS and fatty acid metabolism in cancer has become a focus for the potential diagnosis and treatment of cancer.
Medical subject headings
- Fatty Acid Synthases
- Neoplasms