Development of leprosy and type 1 leprosy reactions after treatment with infliximab: a report of 2 cases.

Scollard, D M; Joyce, M P; Gillis, T P · Clin Infect Dis · 2006

case_report · Level V

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Abstract

Humanized monoclonal antibodies to tumor necrosis factor- alpha are valuable for the treatment of rheumatologic conditions, but they have been associated with the development of serious infections. We report the first 2 cases of leprosy developing after treatment with infliximab. After discontinuation of infliximab, both patients developed type 1 ("reversal") leprosy reactions.

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