Should phosphodiesterase 5 selective inhibitors be used for uterine relaxation?
editorial · Level V
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- Record sourced from PubMed, PMID 16813753.
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Abstract
Sildenafil citrate is a phosphodiesterase 5-selective inhibitor used successfully in treating erectile dysfunction. High doses of sildenafil can inhibit myometrial contractions. However, no study has demonstrated a role for phosphodiesterase 5 in myometrial contractility. No clinical trial using sildenafil to promote uterine relaxation should be initiated based on the currently available data.
Medical subject headings
- 3',5'-Cyclic-GMP Phosphodiesterases
- Phosphodiesterase Inhibitors
- Piperazines
- Uterine Contraction