Promoter cleavage: a topoIIbeta and PARP-1 collaboration.
basic_science · Level V
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Abstract
Hormones trigger dramatic changes in the structure and transcriptional activity of specific promoters that lead to exchange of repression complexes for activation complexes. now show that estrogen-dependent restructuring and transcription of the pS2 promoter require the generation of a DNA double-strand break by a novel protein complex containing two enzymes, topoisomerase IIbeta and poly(ADP-ribose) polymerase.
Medical subject headings
- DNA Topoisomerases, Type II
- DNA-Binding Proteins
- Poly(ADP-ribose) Polymerases
- Promoter Regions, Genetic