p53 aerobics: the major tumor suppressor fuels your workout.
review · Level V
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- Record sourced from PubMed, PMID 16814724.
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Abstract
In addition to its role as the central regulator of the cellular stress response, p53 can regulate aerobic respiration via the novel transcriptional target SCO2, a critical regulator of the cytochrome c oxidase complex (Matoba et al., 2006). Loss of p53 results in decreased oxygen consumption and aerobic respiration and promotes a switch to glycolysis, thereby reducing endurance during physical exercise.
Medical subject headings
- Energy Metabolism
- Tumor Suppressor Protein p53