APPLied mechanics: uncovering how adiponectin modulates insulin action.
review · Level V
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Abstract
Adiponectin, an adipocyte secretory hormone, has been causally linked to insulin resistance in the metabolic syndrome and diabetes. A recent paper (Mao et al., 2006) shows that the APPL1 adaptor protein binds to the intracellular domain of adiponectin receptors and mediates some of adiponectin's actions, identifying a novel mechanism linking adiponectin to insulin sensitization.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Adiponectin
- Carrier Proteins
- Insulin