HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.
other · Level V
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- Record sourced from PubMed, PMID 1681546.
- Also identified by PMC identifier 52618.
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Abstract
A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.
Medical subject headings
- Chromosomes, Human, Pair 10
- Genes, Homeobox
- Homeodomain Proteins
- Oncogene Proteins
- Oncogenes
- T-Lymphocytes