Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony.
review · Level V
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- Record sourced from PubMed, PMID 16823474.
- Also identified by PMC identifier 1483149.
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Abstract
Recent data underscore the importance of intertissue communication in the maintenance of normal glucose homeostasis. Important signals are conveyed by hormones, cytokines, and fuel substrates and are sensed through a variety of cellular mechanisms. The ability of tissues to sense and adapt to changes in metabolic status and fuel availability is altered in insulin-resistant states including type 2 diabetes. Here we review the roles of glucose and its metabolites as signaling molecules and the diverse physiologic mechanisms for glucose sensing.
Medical subject headings
- Energy Metabolism
- Glucose
- Homeostasis