Infrared spectroscopic mapping of single nanoparticles and viruses at nanoscale resolution.
basic_science · Level V
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Abstract
We demonstrate that scattering near-field microscopy (s-SNOM) can determine infrared "fingerprint" spectra of individual poly(methyl methacrylate) nanobeads and viruses as small as 18 nm. Amplitude and phase spectra are found surprisingly strong, even at a probed volume of only 10(-20) l, and robust in regard to particle size and substrate. This makes infrared spectroscopic s-SNOM a versatile tool for chemical and-in the case of protein-secondary-structure identification.
Medical subject headings
- Microscopy
- Nanostructures
- Polymethyl Methacrylate
- Spectroscopy, Near-Infrared
- Viruses